Monday, August 21, 2017

Breast Cancer Hormone Receptors

I recommend searching this in Ovid Medline to make use of adjacency searching.

Estrogen receptor positive:

(estrogen receptor positive or oestrogen receptor positive or er positive or er+ or estrogen receptor +ve or oestrogen receptor +ve or er +ve).mp.
(estrogen receptor adj2 positive).mp.
(oestrogen receptor adj2 positive).mp.

If you don't have access to Ovid Medline, substitute this for the adjacency searches:

"estrogen receptor positive"[tiab] OR "oestrogen receptor positive"[tiab] OR "estrogen receptor alpha positive"[tiab] OR "oestrogen receptor alpha positive"[tiab]

Estrogen receptor negative:

(estrogen receptor negative or oestrogen receptor negative or er negative or er- or estrogen receptor -ve or oestrogen receptor -ve or er -ve).mp.
(estrogen receptor adj2 negative).mp.
(oestrogen receptor adj2 negative).mp.

For PubMed:
"estrogen receptor negative"[tiab] OR "oestrogen receptor negative"[tiab] OR "estrogen receptor alpha negative"[tiab] OR "oestrogen receptor alpha negative"[tiab]

Progesterone receptor positive:

(progesterone receptor positive or pr positive or pgr positive or pr+ or pgr+ or progesterone receptor +ve or pr +ve or pgr +ve).mp.
(progesterone receptor adj2 positive).mp.

Progesterone receptor negative:

(progesterone receptor negative or pr negative or pgr negative or pr- or pgr- or progesterone receptor -ve or pr -ve or pgr -ve).mp.
(progesterone receptor adj2 negative).mp.

Human epidermal growth factor positive:

(human epidermal growth factor adj3 positive).mp.
or
(her2 positive or her2-neu positive or erbb2 positive or her2+ or "her2/neu+" or erbb2+ or her2 +ve or her2-neu +ve or erbb2 +ve).mp.

Human epidermal growth factor negative:

(human epidermal growth factor adj3 negative).mp.
or
(her2 negative or her2-neu negative or erbb2 negative or her2- or "her2/neu-" or erbb2- or her2 –ve or her2-neu –ve or erbb2 -ve).mp.

Additional, more general keywords:

(hormone receptor positive or hr positive or hormone receptor double positive or estrogen receptor progesterone receptor positive or er+pr+ or er+pgr+ or hormone receptor +ve or hr +ve or luminal a or luminal b or normal like).mp.
(hormone receptor adj2 positive).mp.

May be relevant depending on the specific question:

(triple negative or basal like).mp.

(her2 enriched).mp.

Definitions:

Luminal A: ER+PR+HER2-, low levels of Ki-67
Luminal B: ER+PR+, HER2 either + or -, high levels of Ki-67
Triple negative: ER-PR-HER2-
HER2 enriched: ER-PR-HER2+
Normal-like: ER+PR+HER2, low levels of Ki-67